反应详情

A solution of (5R)-3-(6-{2-[(4-aminobenzyl)oxy]ethoxy}hexyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one (150 mg) in dichloromethane (5 ml) under nitrogen was treated with phenyl isocyanate (0.07 ml) and the mixture stirred at 20° for 5 h. Isopropyl alcohol (5 ml) was added and the solution was stirred for a further 18 h. The solvent was evaporated in vacuo and the residue purified by SPE (silica, 10 g). Elution with EtOAc—cyclohexane (3:7) then EtOAc gave the title compound (159 mg). LCMS RT=3.68 min.

1. stirringthe solution was stirred for a further 18 h
2. customThe solvent was evaporated in vacuo
3. customthe residue purified by SPE (silica, 10 g)
4. washElution with EtOAc—cyclohexane (3:7)