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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 901731Generated: October 25, 2026

4-Chloropyridine → [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine

https://huagongshe.com/reaction/901731

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChloropyridineHCID 12288—
Reactant2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamineHCID 59699242—
SolventDimethylformamideHCID 6228—
Product[2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amineHCID 59699105—

Reaction Conditions

Temperature100 °C

Reaction Steps

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine, the product of Example 512, was treated with 4-chloropyridine in DMF and was heated at 100° C. Aqueous workup and chromatography on silica gel afforded Example 519. (Yield: 80 mg)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07361678B2
Source datasetuspto-grants-2008_04
ORD IDord-f0758d4cb2664e00a09e4d55d1c9077f
Source noteuspto-grants-2008_04