Hydrochloric Acid → HCID 11583653, compound

Participants

Reaction Steps

The compound (53 mg, 40.4 mmol) synthesized in Example 14 (14f) was dissolved in methanol (10 mL) and hydrochloric acid (10 μL) and 20% palladium hydroxide-carbon (53 mg) were added thereto, followed by stirring of the mixture at room temperature under a hydrogen atmosphere for 4 hours. After celite filtration, the solvent was distilled off under reduced pressure and the residue was purified by ion exchange resin (Dowex 50w×8) column (water—5% ammonia water). Further, it was purified using silica gel flash column chromatography (ethyl acetate:methanol:water, 1:1:1, V/V) to obtain the desired title compound (5 mg, 26%) as a colorless solid.

Provenance & Evidence