HCID 86602942, compound → HCID 68440119, compound

HRID 901802Notes

Reaction equation

HRID 901802 reaction equation
[C:1]([O:9][C@H:10]([CH:25]=[CH2:26])[C@H:11]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C@@H:12]([F:16])[CH:13]=[N:14][OH:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1(C)C=CC=CC=1>[C:1]([O:9][C@@H:10]1[C@@H:25]2[C@@H:13]([NH:14][O:15][CH2:26]2)[C@H:12]([F:16])[C@H:11]1[O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 86602942HCID 86602942, compound

Product 1

HCID 68440119HCID 68440119, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
120 °C

Procedure

The compound (1.31 g, 3.66 mmol) synthesized in Example 17 (17e) was dissolved in toluene (30 mL) and the mixture was stirred at 120° C. for 8 hours. The solvent was distilled off under reduced pressure and the residue was purified using silica gel flash column chromatography (hexane:ethyl acetate, 3:1, V/V) to obtain the desired title compound (965 mg, yield 74%) as a colorless solid.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified

Sources & evidence

ORD record
ord-4780d11092f34cdb9894a8027ca136c2
Source dataset
uspto-grants-2008_04
Patent number
US07361744B2

Reaction notes

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