Methanol → Maleimide styrene

Participants

Reaction Conditions

Reaction Steps

2.74 g (9.033 mmol) of polyhydroxymaleimide-polyhydroxystyrene was dissolved in 50 ml of N-methylpyrrolidone (NMP). After the solution was cooled to 0° C., 3.291 g (32.52 mmol) of triethylamine (Et3N) was added thereto. The mixture was stirred for 30 minutes. 6.995 g (21.679 mmol) of 3,4-difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester was added to the mixture and stirred at room temperature for 4 hours. The reaction solution was poured into an aqueous solution of methanol, and filtered to obtain a solid. The solid was washed with water several times and dried in vacuo, affording the desired compound 2 (yield: 60%).

Provenance & Evidence