Hydrochloric Acid → HCID 9945666, compound

Participants

Reaction Steps

The crude methyl 2-ethoxy-3-[4-(N-heptylimiomethyl)phenyl]propanoate obtained in step (i) above (2.95 g), was dissolved in methanol (40 ml), and treated with conc. HCl (850 μl, 1 eq, 8.51 mmol) and sodium cyanoborohydride (535 mg, 1 eq, 8.51 mmol) at 0° C. The progress of the reaction was monitored by TLC. After 2-3 h, the reaction mixture was diluted with ethyl acetate, washed with aqueous sodium bicarbonate and dried over anhydrous sodium sulfate. The residue was chromatographed using methanol and chloroform to afford the title compound (1.71 g, yield 60%) as viscous liquid.

Provenance & Evidence