2-Nitrophenol → ethyl 2-(2-nitrophenoxy)propanoate

HRID 901836Notes

Reaction equation

HRID 901836 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].Br[CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 69472-NitrophenolHCID 79040Ethyl 2-bromopropionate

Product 1

HCID 292529ethyl 2-(2-nitrophenoxy)propanoate

Procedure

Starting from 2-nitrophenol (10 g, 1 eq, 71.9 mmol) and ethyl 2-bromopropionate (10.2 ml, 1.1 eq, 79.09 mmol) the procedure of Step (i), preparation 17 was followed to obtain ethyl 2-(2-nitrophenoxy)propanoate in crude form (16 g) which was used for step (ii).

Workup

  1. customthe procedure of Step (i), preparation 17

Sources & evidence

ORD record
ord-007ec6093fd544ee9500a6fe32596831
Source dataset
uspto-grants-2008_04
Patent number
US07365064B2

Reaction notes

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