2-Nitrophenol → Ethyl 2-(2-nitrophenoxy)pentanoate

HRID 901838Notes

Reaction equation

HRID 901838 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].Br[CH:12]([CH2:18][CH2:19][CH3:20])[C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH:12]([CH2:18][CH2:19][CH3:20])[C:13]([O:15][CH2:16][CH3:17])=[O:14])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 69472-NitrophenolHCID 79071Ethyl 2-bromovalerate

Product 1

HCID 69205260Ethyl 2-(2-nitrophenoxy)pentanoateYield 104.1%

Procedure

Starting from 2-nitrophenol (1.0 g, 1 eq, 7.19 mmol) and ethyl 2-bromopentanoate (2.97 ml, 3.0 eq, 21.54 mmol) the procedure of step (i), preparation 17 was followed to obtain ethyl 2-(2-nitrophenoxy)pentanoate (2.0 g) as crude which was used for step (ii).

Workup

  1. customthe procedure of step (i), preparation 17

Sources & evidence

ORD record
ord-5eb4972e5fbd4b55adc8e3028d5e147b
Source dataset
uspto-grants-2008_04
Patent number
US07365064B2

Reaction notes

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