HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → Ethyl 4-nitro-L-phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Ethyl 4-nitro-3-phenyl-L-alaninate monohydrochloride | HCID 6453710 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 4-nitro-L-phenylalanine | HCID 6453711 | 89.4% |
Reaction Steps
4-nitrophenylalanine ethyl ester hydrochloride (2 g, 1.0 eq, 7.28 mmol) obtained in step (i) was dissolved in ethyl acetate (150 mL). To that Na2CO3 (386 mg, 0.5 eq, 3.64 mmol) was added and was stirred for 15 min. The reaction mixture was washed with aq. NaHCO3. The organic layer was dried (Na2SO4), and condensed to obtain 4-nitrophenylalanine ethyl ester as thick oil (1.55 g, 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365064B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-6d9d778bacb445ec9896a92e01a018b3 |
| Source note | uspto-grants-2008_04 |