Benzene → HCID 178467708, compound

Participants

Reaction Steps

To a solution of 3-[4-{3-(3,4-dihydro-2H-benzo[b][1,4]oxazin-4-yl)propylamino}phenyl]-2-ethoxypropanoic acid (200 mg, 1 eq, 0.52 mmol) obtained in example 2, in dry methanol:dichloroethane (10:1) (5 ml), L-arginine (90.5 mg, 1 eq, 0.52 mmol) was added and allowed to stir for 3-4 h. The solvent was reduced on rotavapour followed by benzene azeotrope. The residue was dried under high vacuum pump to yield the title compound as a free flowing solid (yield 100%), mp: 92-94° C.

Provenance & Evidence