HCID 10134629, compound → HCID 178467699, compound

HRID 901847Notes

Reaction equation

HRID 901847 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][NH:10][C:11]2[CH:12]=[C:13]([CH2:17][CH:18]([O:22][CH2:23][CH3:24])[C:19]([OH:21])=[O:20])[CH:14]=[CH:15][CH:16]=2)[C:3]2[CH:25]=[CH:26][CH:27]=[CH:28][C:2]1=2.[NH2:29][C@H:30]([C:38]([OH:40])=[O:39])[CH2:31][CH2:32][CH2:33][NH:34][C:35](=[NH:37])[NH2:36]>CO>[NH2:29][C@H:30]([C:38]([OH:40])=[O:39])[CH2:31][CH2:32][CH2:33][NH:34][C:35](=[NH:36])[NH2:37].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][NH:10][C:11]2[CH:12]=[C:13]([CH2:17][CH:18]([O:22][CH2:23][CH3:24])[C:19]([OH:21])=[O:20])[CH:14]=[CH:15][CH:16]=2)[C:3]2[CH:25]=[CH:26][CH:27]=[CH:28][C:2]1=2

Participants

4

Reactant 2

HCID 10134629HCID 10134629, compoundHCID 178418600HCID 178418600, compound

Product 1

HCID 178467699HCID 178467699, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-[3-{3-(3,4-Dihydro-2H-benzo[b][1,4]oxazin-4-yl)propylamino}phenyl]-2-ethoxypropanoic acid (90 mg, 1 eq, 0.23 mmol) obtained in example 14, and L-arginine (40.8 mg, 1 eq, 0.23 mmol) were taken in dry methanol (5 ml), and stirred at RT for 2-3 h. The solvent was removed on rotavapour followed by benzene azeotrope. The residue was dried under high vacuum pump to yield the title compound as a free flowing solid (yield 100%), mp: 178-180° C.

Workup

  1. customThe solvent was removed on rotavapour
  2. customThe residue was dried under high vacuum pump

Sources & evidence

ORD record
ord-bc69e8794b0e43d7bd801b84d228888a
Source dataset
uspto-grants-2008_04
Patent number
US07365064B2

Reaction notes

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