Lithium hydroxide, monohydrate → HCID 10201121, compound

Participants

Reaction Steps

Methyl 3-[4-{3-(7-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazin-4-yl)propylamino}phenyl]-2-ethoxypropanoate (180 mg, 1 eq, 0.43 mmol) obtained in example 16, was hydrolyzed using lithium hydroxide monohydrate (55 mg, 3 eq, 1.2 mmol), in methanol-water at RT till all the starting material is consumed (4 to 5 h). The reaction mixture was diluted with water, acidified (pH ˜4-5) with dil. HCl and then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated on rotary evaporator. The residue was chromatographed using ethyl acetate and hexanes→methanol and chloroform to afford the title compound (121 mg, yield 70%) as viscous liquid.

Provenance & Evidence