Hydrochloric Acid → 1-Benzyl-5-piperazin-1-yl-1,4-dihydro-benzo[d]1,3oxazin-2-one

Participants

Reaction Conditions

Reaction Steps

4-(1-Benzyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester (33 mg, 0.08 mmol) was dissolved in 4 ml ethanol. To this solution was added 2 M ethanolic hydrochloric acid solution (1 ml). The reaction mixture was heated at 100° C. for 20 minutes, at which time a crystalline solid formed. The solution was allowed to cool to room temperature and 13 mg of 1-Benzyl-5-piperazin-1-yl-1,4-dihydro-benzo[d][1,3]oxazin-2-one hydrochloride salt was collected a light yellow powder. MS: 324 (M+H)+.

Provenance & Evidence