Diethyl Ether → HCID 11349226, compound

HRID 901886Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]3[C:15]=2[CH2:16][NH:17][C:18](=[O:34])[N:19]3[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.CCOCC>Cl.C(O)C>[F:33][C:29]1[CH:28]=[C:27]([CH:32]=[CH:31][CH:30]=1)[CH2:26][N:19]1[C:20]2[C:15](=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=2)[CH2:16][NH:17][C:18]1=[O:34]

Participants

Conditions

Temperature: 80 °C

Procedure

4-[1-(3-Fluoro-benzyl)-7-methoxy-2-oxo-1,2,3,4-tetrahydro-quinazolin-5-yl]-piperazine-1-carboxylic acid tert-butyl ester (43 mg) was dissolved in 4 mL 2N HCl/ethanol and heated to 80° C. for 20 minutes. The reaction mixture was cooled to room temperature, and ether was added, precipitating 18 mg of 1-(3-fluoro-benzyl)-7-methoxy-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one. MS: 371 (M+H)+.

Workup

temperatureThe reaction mixture was cooled to room temperature
customprecipitating 18 mg of 1-(3-fluoro-benzyl)-7-methoxy-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one

Sources & evidence

ORD record: ord-c12f8e471cc24e7c8df71759963e73c6
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365063B2

Reaction notes

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