4-Fluoroaniline → HCID 178503195, compound

HRID 901898Notes

Reaction equation

HRID 901898 reaction equation
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH:16][C:7]([C:6]2[CH:9]=[CH:10][C:3]([S:2][CH3:1])=[CH:4][CH:5]=2)=[NH:8])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 5909604-(Methylthio)benzonitrile

Product 1

HCID 178503195HCID 178503195, compound

Procedure

The title compound was prepared from 4-methylthiobenzonitrile (0.50 g, 33.6 mmol) and 4-fluoroaniline (0.372 g, 33.6 mmol) by following the procedure described in preparation 1, (0.43 g, 49.3%, mp 145-147° C., purity 94.7% by HPLC). 1H-NMR (CDCl3):δ 2.52 (s, 3H), 6.93-6.94 (m, 3H), 7.17-7.32 (m, 5H). MS m/z:261.1(M+)

Workup

  1. customdescribed in preparation 1, (0.43 g, 49.3%, mp 145-147° C., purity 94.7% by HPLC)

Sources & evidence

ORD record
ord-7c14a35db9cd477f9d5d057b8cd6c86b
Source dataset
uspto-grants-2008_04
Patent number
US07365069B2

Reaction notes

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