Pyridine-2-carbonitrile → HCID 178492292, compound

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Reaction Steps

The title compound was prepared from 2-cyanopyridine (8.46 g, 81 mmol) and 4-methoxyaniline (10 g, 81 mmol) by following the procedure described in preparation 10 (16 g, yield 86.7%, mp 73-75° C., purity 97.6% by HPLC). 1H-NMR (CDCl3):δ 3.81 (s, 3H), 5.5-6 (bs, 2H, D2O exchangeable), 6.91-6.98 (m, 4H), 7.37-7.4 (m, 1H), 7.79-7.83 (m, 1H), 8.39-8.41 (d, 1H), 8.56-8.57 (d, 1H). IR (KBr) cm−1: 3456, 3540, 3410, 1663. MS m/z:228.2 (M+).

Provenance & Evidence