1,4-Dioxane hydrochloride → HCID 86614602, compound

Participants

Reaction Steps

68.2 mg (0.079 mmol) of the obtained 2-[((2S)-1′-{2-[(2R)-4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4′-piperidin]-2-yl)oxy]-N-[2-(2-hydroxyethoxy)ethyl]-N-methylacetamide was dissolved in 5 mL of methylene chloride and 0.2 mL of 4N hydrochloric acid-dioxane solution was added dropwise thereto. The solvent was distilled off under reduced pressure and the thus obtained amorphous matter was collected by filtration by adding n-hexane to obtain 63.6 mg (yield: 89%) of the title compound as a white solid.

Provenance & Evidence