Ethanol → Ethyl 4-(methylamino)butanoate hydrochloride
Reaction equation
[ClH:1].[CH3:2][NH:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].S(=O)(=O)(O)O.[CH2:15](O)[CH3:16]>>[ClH:1].[CH3:2][NH:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:15][CH3:16])=[O:8]Participants
4
Conditions
- Temperature
- 90 °C
Procedure
2.00 g (13.0 mmol) of 4-(methylamino)butanoic acid hydrochloride was dissolved in 40 mL of ethanol and 69 μL (1.30 mmol) of concentrated sulfuric acid was added thereto, followed by stirring of the mixture at 90° C. for 1 hour. The solvent was distilled off under reduced pressure, followed by azeotropy with toluene. 3.02 g of the obtained residue was used for the subsequent reaction as such.
Workup
- distillationThe solvent was distilled off under reduced pressure
- custom3.02 g of the obtained residue was used for the subsequent reaction as such
Sources & evidence
- ORD record
- ord-0d58a42f49a149cb954b3628d9d9c5dc
- Source dataset
- uspto-grants-2008_04
- Patent number
- US07365067B2
Reaction notes
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