Hydrochloric Acid → HCID 86605147, compound

Participants

Reaction Steps

To a solution of trans 3-benzylamino-5-carboethoxymethoxy-2-hydroxy-1,2,3,4-tetrahydronaphthalene (10 g) in 95% aqueous ethanol (200 mL) was added dropwise concentrated aqueous hydrochloric acid solution to bring the pH to 6. Addition of 5% palladium on carbon was followed by hydrogenation on a Parr apparatus at 50 psi for 1 day. The mixture was filtered, rinsing the catalyst with 95% aqueous ethanol and methanol. The filtrate was evaporated to yield a residue. The residue was recrystallized from a mixture of methanol and absolute ethanol to provide the title product (5.2 g, m.p. 210-211° C.).

Provenance & Evidence