HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 902021Generated: October 28, 2026
Dimethylformamide → HCID 59700619, compound
https://huagongshe.com/reaction/902021
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Bromo-2-Chloroethane | HCID 7849 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 135983747 | HCID 135983747 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 59700619 | HCID 59700619 | 30% |
Reaction Steps
4-(2-Pyridin-2-yl-pyrazolo[1,5-a]pyridin-3-yl)-quinolin-7-ol in a solution of DMF and MeOH was treated with 1-bromo-2-chloroethane (3 equiv) and cesium carbonate (2 equiv). The reaction was heated to 60° C. and stirred overnight. As described above, the desired product was then obtained upon chromatographic purification (EtOAc, followed by MeOH, then 2 M NH3 in MeOH). Yield; 30% overall from Prep. 90. MS ES+ m/e 401.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07365066B2 |
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| Source dataset | uspto-grants-2008_04 |
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| ORD ID | ord-d7940a90f7e0431eac37fc5bb250248f |
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| Source note | uspto-grants-2008_04 |
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