HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 902024Generated: October 31, 2026
Diisopropylethylamine → HCID 59700605, compound
https://huagongshe.com/reaction/902024
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Pyridinium, 1-amino-, iodide (1:1) | HCID 2733704 | — |
| Reactant | HCID 21992663 | HCID 21992663 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 59700605 | HCID 59700605 | 19% |
Reaction Steps
Add 1-aminopyridinium iodide (780 mg, 3.53 mmol), N,N-diisopropylethylamine (0.62 mL, 3.53 mmol), 1-(6-chloro-pyridin-2-yl)-2-quinolin-4-yl-ethanone (500 mg, 1.77 mmol), and ethanol (8 mL) to a sealed tube apparatus. The sealed vessel is heated at 110° C. for 5 hours. After cooling, the crude is concentrated in vacuo. Purification by flash column chromatography (Silica Gel, 25-40% acetone/hexanes) provides the title compound 119 mg (19%) as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07365066B2 |
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| Source dataset | uspto-grants-2008_04 |
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| ORD ID | ord-4aa5bfcba0244271bc6ed9ee9b57fe79 |
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| Source note | uspto-grants-2008_04 |
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