Triphenylphosphine → HCID 59700621, compound

Participants

Reaction Conditions

Reaction Steps

Combine 7-bromo-4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[1,5-a]pyridin-3-yl]-quinoline (0.18 g, 0.43 mmol), triphenylphosphine (36 mg, 0.14 mmol), sodium acetate (0.05 g, 0.61 mmol), methanol (2.7 mL), and DMF (2.7 mL). Bubble nitrogen gas through the solution for 10 minutes. Add palladium acetate (0.03 g, 0.13 mmol). Bubble nitrogen gas through the solution for another 10 minutes. Connect a carbon monoxide balloon to the reaction vessel and heat at 80° C. for 24 hours. Evaporate the solvent in vacuo. Chromatograph the residue on silica gel (elute with 50% ethyl acetate/hexanes then 75% ethyl acetate/hexanes) to afford the title compound 72 mg (42%) as a yellowish solid.

Provenance & Evidence