Triisopropyl borate → HCID 10382614, compound

Participants

Reaction Conditions

Reaction Steps

Stir 3-bromo-2-(6-methyl-pyridin-2-yl)-pyrazolo[1,5-a]pyridine (500 mg, 1.74 mmol) in THF (20 ml) at −60° C. and add t-butyl lithium (4 ml, 6.94 mmol, 1.7M in pentane). Stir for 1 hour, then add tri-isopropyl borate (1.2 ml, 5.2 mmol) and warm to 0° C. for 1 hour. Quench with 1M HCl (5 ml). Concentrate in vacuo and redissolve in a 2:1 toluene/methanol mixture (30 ml). Adjust to pH 8 with aqueous 2M Na2CO3. Add 100 mg Pd(PPh3)4 and 2,2,2-trifluoro-N-(6-iodo-imidazo[1,2-a]pyridin-2-yl)-acetamide (200 mg, 563 mmol) and heat to 90° C. for 18 hours. Acidify with 1M HCl and extract with ethyl acetate (3×100 ml). Neutralize aqueous layer with 5N NaOH and extract with ethyl acetate (3×100 ml). Concentrate organic layer in vacuo and purify on Silica gel (eluting with 70/30 Hexane/EtOAc). MS ES+ m/e 341.1 (M+1).

Provenance & Evidence