HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 9899684, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 23500890 | HCID 23500890 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 9899684 | HCID 9899684 | 25.3% |
Reaction Steps
2-[1,2-Dibromo-2-(3-fluorophenyl)ethyl]-6-methylpyrazine (2.97 g, 7.94 mmol) was dissolved in THF (40 mL), treated with DBU (8.7 mL, 63 mmol), and heated to reflux. After 16 h the reaction mixture was cooled, filtered, concentrated in vacuo, and purified by column chromatography eluting with 80:20 then 75:25 hexane:ethyl acetate to afford 2-[(3-fluorophenyl)ethynyl]-6-methylpyrazine (427 mg, 25% yield). This material was carried on to the salt formation without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365074B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-c8e37b6db3bd49d08ca9ecb0998fa545 |
| Source note | uspto-grants-2008_04 |