HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → Ethyl 4-[(4-(2-pyridyloxy)phenyl)methyl]piperazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | (4-(2-Pyridyloxy)phenyl)methyl chloride | HCID 22292927 | — |
| Product | Ethyl 4-[(4-(2-pyridyloxy)phenyl)methyl]piperazinecarboxylate | HCID 69313800 | 99.6% |
Reaction Steps
This compound was prepared in a manner analogous to that of Example 2, Step D, using 2.2 grams (0.010 mole) of 4-(2-pyridyloxy)phenylmethyl chloride, 1.6 grams (0.010 mole) of ethyl 1-piperazinecarboxylate, and 3.9 grams (0.030 mole) of DMSO, yielding 3.4 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365082B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-2befccb730454675af5533859ae23946 |
| Source note | uspto-grants-2008_04 |