3-Bromobenzaldehyde → 2-(3-Bromophenyl)-4-iodomethyl-5-methyloxazole

HRID 902116Notes

Reaction equation

HRID 902116 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[Br:28]C1C=C(C=CC=1)C=O>>[Br:28][C:16]1[CH:15]=[C:14]([C:5]2[O:6][C:7]([CH3:8])=[C:3]([CH2:2][I:1])[N:4]=2)[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 765833-BromobenzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 224936472-(3-Bromophenyl)-4-iodomethyl-5-methyloxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and 3-bromobenzaldehyde gave 2-(3-bromophenyl)-4-iodomethyl-5-methyloxazole.

Sources & evidence

ORD record
ord-405f0ced68b24d9f811da6ee081a0a71
Source dataset
uspto-grants-2008_04
Patent number
US07365084B2

Reaction notes

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