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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 902117Generated: October 25, 2026

3-(Trifluoromethyl)benzaldehyde → 2-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazole

https://huagongshe.com/reaction/902117

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzaldehydeHCID 67990—
Reactant2,3-Butanedione monoximeHCID 6409633—
Reactant4-Iodomethyl-5-phenyl-2-p-tolyloxazoleHCID 57434504—
Product2-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazoleHCID 22493681—

Reaction Steps

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and 3-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(3-trifluoromethylphenyl)oxazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07365084B2
Source datasetuspto-grants-2008_04
ORD IDord-4be209de2c78469fa03e9fdc8628825a
Source noteuspto-grants-2008_04