2-Naphthalenecarboxaldehyde → HCID 58934209, compound

HRID 902128Notes

Reaction equation

HRID 902128 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1[CH:13]=CC=CC=1.[CH3:21][C:22](=NO)[C:23](=O)CC.C1C2C(=CC=CC=2)C=CC=1C=O>>[CH2:8]([C:7]1[O:6][C:5]([C:14]2[CH:15]=[CH:16][C:17]3[C:18](=[CH:21][CH:22]=[CH:23][CH:20]=3)[CH:19]=2)=[N:4][C:3]=1[CH2:2][I:1])[CH3:13]

Participants

4

Reactant 3

HCID 62012-NaphthalenecarboxaldehydeHCID 67974532,3-Pentanedione, 2-oximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 58934209HCID 58934209, compound

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, pentane-2,3-dione-2-oxime and naphthalene-2-carbaldehyde gave 5-ethyl-4-iodomethyl-2-naphthalen-2-yloxazole.

Sources & evidence

ORD record
ord-dbfeff6f85444f39b4f8f7b09b1e5423
Source dataset
uspto-grants-2008_04
Patent number
US07365084B2

Reaction notes

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