3,4-Dimethylbenzaldehyde → HCID 59701351, compound

HRID 902130Notes

Reaction equation

HRID 902130 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1[CH:13]=CC=CC=1.[CH3:21]C(=NO)C(=O)CC.CC1C=C(C=CC=1C)C=O>>[CH3:21][C:18]1[CH:19]=[C:14]([C:5]2[O:6][C:7]([CH2:8][CH3:13])=[C:3]([CH2:2][I:1])[N:4]=2)[CH:15]=[CH:16][C:17]=1[CH3:20]

Participants

4

Reactant 3

HCID 222783,4-DimethylbenzaldehydeHCID 67974532,3-Pentanedione, 2-oximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 59701351HCID 59701351, compound

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, pentane-2,3-dione-2-oxime and 3,4-dimethylbenzaldehyde gave 2-(3,4-dimethylphenyl)-5-ethyl-4-iodomethyloxazole.

Sources & evidence

ORD record
ord-5a2f3ec9d84f4ef4868e2d257fb302b2
Source dataset
uspto-grants-2008_04
Patent number
US07365084B2

Reaction notes

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