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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 902131Generated: October 31, 2026

4-(Trifluoromethyl)benzaldehyde → 4-Iodomethyl-5-isopropyl-2-(4-trifluoromethylphenyl)-oxazole

https://huagongshe.com/reaction/902131

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzaldehydeHCID 67996—
Reactant4-Methylpentane-2,3-dione 2-oximeHCID 57357475—
Reactant4-Iodomethyl-5-phenyl-2-p-tolyloxazoleHCID 57434504—
Product4-Iodomethyl-5-isopropyl-2-(4-trifluoromethylphenyl)-oxazoleHCID 59701378—

Reaction Steps

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, 4-methylpentane-2,3-dione-2-oxime and 4-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-isopropyl-2-(4-trifluoromethylphenyl)-oxazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07365084B2
Source datasetuspto-grants-2008_04
ORD IDord-e81abe1a742343c19dc9bd5c16844de6
Source noteuspto-grants-2008_04