6-Methoxy-1H-benzimidazole-2-carboxylic acid → 6-Hydroxy-1H-benzimidazole-2-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 26.0 g (105 mmol) of 6-methoxy-1H-benzoimidazole-2-carboxylic acid butilamide and 780 ml of 48% aqueus hydrobromic acid is stirred at 110° C. for 8 h, then refluxed for 12 h. The mixture is cooled to room temperature, the precipitated product is filtered off, washed with water until pH neutral and dried to yield 14.3 g (76.2%) of the title compound. Mp.: 206-207° C. (water).

Provenance & Evidence