Cesium carbonate → HCID 86760645, compound

Participants

Reaction Steps

To a solution of 200 mg 3-Formyl-1H-indazole-5-carboxylic acid methyl ester in 4 mL DMF, 273 mg 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole [prepared by adopting a procedure described by Ewing, William R.; Becker, Michael R.; Choi-Sledeski, Yong Mi; Pauls, Heinz W.; He, Wei; Condon, Stephen M.; Davis, Roderick S.; Hanney, Barbara A.; Spada, Alfred P.; Burns, Christopher J.; Jiang, John Z.; Li, Aiwen; Myers, Michael R.; Lau, Wan F.; Poli, Gregory B; PCT Int. Appl. (2001) 460 pp. WO 0107436 A2] and 320 mg Cs2CO3 were added and the mixture was stirred at room temperature for 1.5 h. This crude reaction mixture was subjected to the subsequent oxidation step.

Provenance & Evidence