HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 51110170, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Indazole-3-carboxylic acid | HCID 78250 | — |
| Reactant | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| Reactant | 1-Isopropylpiperidin-4-amine hydrochloride | HCID 23033460 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 51110170 | HCID 51110170 | — |
Reaction Steps
To a solution of 300 mg 1H-Indazole-3-carboxylic acid in 3 mL DMF and 1 mL NEt3, 398 mg 1-Isopropyl-piperidin-4-ylamine hydrochloride and 471 mg BOP-Cl were added at RT and the mixture was stirred for 16 h. After the addition of 5 mL water the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate and then concentrated under reduced pressure. The residue was directly subjected to the subsequent alkylation reaction without further purification. Yield: 340 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365088B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-76a1f291816c470ba4b9a5a7aa675cc2 |
| Source note | uspto-grants-2008_04 |