Hydrochloric Acid → HCID 178456286, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 200 mg 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-1H-indazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide in 3 mL methanol, 27 mg NH2OH*HCl and 44 mg KOt-Bu were added and the mixture was heated to 50° C. for 3 d. After cooling to RT the precipitated inorganic salts were filtered off. The precipitate was washed with methanol (2×5 ml) and the combined filtrates were collected and concentrated under reduced pressure. The residue was subjected to the next reaction step without further purification. Yield: 223 mg.

Provenance & Evidence