Water → HCID 86760649, compound

Participants

Reaction Steps

To a solution of 100 mg 1H-indazole-3-carboxylic acid in 2 mL DCM and 0.3 mL NEt3, 125 mg (4-Amino-phenyl)-piperidin-1-yl-methanone and 157 mg BOP-Cl were added at RT and the mixture was stirred for 16 h. After the addition of 5 mL water the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate and then concentrated under reduced pressure. The residue was directly subjected to the subsequent alkylation reaction without further purification.

Provenance & Evidence