Water → HCID 11443666, compound

Participants

Reaction Steps

To a solution of 4 g 3-(1-Isopropyl-piperidin-4-ylcarbamoyl)-1H-indazole-5-carboxylic acid methyl ester in 35 mL DMF, 3.8 g Cs2CO3 and 2.9 g 2-Bromo-N-(5-chloro-pyridin-2-yl)-acetamide were added at RT and the reaction mixture was stirred for 2 d. After addition of 50 mL water the mixture was extracted with ethyl acetate (3×150 mL), the combined organic layers were dried over MgSO4 and filtered. The solvents were removed under reduced pressure and the residue was recrystallized from diisopropylether. Yield: 3.8 g MS (ES+): m/e=513, chloro pattern.

Provenance & Evidence