1,4-Dioxane hydrochloride → N-Propyl-N-propoxyamine hydrochloride

HRID 902232Notes

Reaction equation

HRID 902232 reaction equation
C([N:8]([CH2:13][CH2:14][CH3:15])[O:9][CH2:10][CH2:11][CH3:12])(OC(C)(C)C)=O.[ClH:16].O1CCOCC1>>[ClH:16].[CH2:13]([NH:8][O:9][CH2:10][CH2:11][CH3:12])[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22322626N-Boc-N-propyl-N-propoxyamine

Product 1

HCID 22322517N-Propyl-N-propoxyamine hydrochloride

Procedure

N-Boc-N-propyl-N-propoxyamine (5.8 g) was dissolved in 4 N HCl/dioxane (10 mL) and stirred at room temperature for 7 hours. The solvent was removed in vacuo and the residue triturated with diethyl ether. The resulting yellow solid (2.1 g) was collected by filtration and washed with diethyl ether.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with diethyl ether
  3. filtrationThe resulting yellow solid (2.1 g) was collected by filtration
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-67d8f1683bbc4d55a2750f9093c1e7c3
Source dataset
uspto-grants-2008_04
Patent number
US07365093B2

Reaction notes

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