HCID 68853303, compound → HCID 11293202, compound

HRID 902263Notes

Reaction equation

HRID 902263 reaction equation
[ClH:1].Cl.CN[C@H]1CCN(CC(C2CCCCC2O)C2C3C(=CC=CC=3)C=CC=2)C1.[OH:29][C:30]1([CH:36]([C:52]2[C:61]3[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=3)[CH:55]=[CH:54][CH:53]=2)[C:37]([N:39]2[CH2:43][CH2:42][C@H:41]([NH:44][C:45](=O)OC(C)(C)C)[CH2:40]2)=O)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>>[ClH:1].[ClH:1].[CH3:45][NH:44][C@H:41]1[CH2:42][CH2:43][N:39]([CH2:37][CH:36]([C:30]2([OH:29])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]2)[C:52]2[C:61]3[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=3)[CH:55]=[CH:54][CH:53]=2)[CH2:40]1

Participants

3

Reactant 2

HCID 68853303HCID 68853303, compoundHCID 86599037HCID 86599037, compound

Product 1

HCID 11293202HCID 11293202, compound

Procedure

In an analogous manner to Example 13, step 2, 1-[2-[(3S)-3-(methylamino)pyrrolidin-1-yl-1-(1-naphthyl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl {(3S)-1-[(1-hydroxycyclohexyl)(1-naphthyl)acetyl]pyrrolidin-3-yl}carbamate MS (ESI) m/z 353; HRMS: calcd for C23H32N2O+H, 353.25929; found (ESI, [M+H]+), 353.2589.

Sources & evidence

ORD record
ord-5889e22798fd4833a8c3e8b2c3b213ee
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

Loading…