HCID 68853384, compound → HCID 86599045, compound

HRID 902268Notes

Reaction equation

HRID 902268 reaction equation
[ClH:1].Cl.N1([CH2:9][CH:10]([C:28]2([OH:34])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[C:11]2[CH:12]=[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][C:24]([F:27])([F:26])[F:25])[CH:18]=3)[CH:14]=[CH:15][CH:16]=2)CCNCC1.FC(F)(F)OC1C=C(C2C=CC=C(C(C3(O)CCCCC3)C[N:52]3[CH2:57][CH2:56][N:55](C(OC(C)(C)C)=O)[CH2:54][CH2:53]3)C=2)C=CC=1>>[ClH:1].[ClH:1].[N:52]1([CH:33]2[CH2:32][CH2:31][CH2:30][CH2:29][C:28]2([CH:10]([C:11]2[CH:12]=[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][C:24]([F:26])([F:25])[F:27])[CH:18]=3)[CH:14]=[CH:15][CH:16]=2)[CH3:9])[OH:34])[CH2:57][CH2:56][NH:55][CH2:54][CH2:53]1

Participants

3

Reactant 2

HCID 68853384HCID 68853384, compoundHCID 68853921HCID 68853921, compound

Product 1

HCID 86599045HCID 86599045, compound

Procedure

In an analogous manner to Example 135, step 4 1-{2-piperazin-1-yl-1-[3′-(trifluoromethoxy)-1,1′-biphenyl-3-yl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-(3′-trifluoromethoxy-biphenyl-3-yl)-2-(1-hydroxycyclohexyl)ethyl]piperazine-1-carboxylate. MS (ESI) m/z 449; HRMS: calcd for C25H31F3N2O2+H, 449.24159; found (ESI, [M+H]+), 449.2434.

Sources & evidence

ORD record
ord-b3c5bf4f95e040faa77a8e3b7083a98e
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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