HCID 68852257, compound → HCID 68852181, compound

HRID 902276Notes

Reaction equation

HRID 902276 reaction equation
[ClH:1].Cl.[N:3]1([CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH:16]([C:29]3([OH:35])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)[C:17]3[CH:26]=[CH:25][C:24]4[C:19](=[CH:20][CH:21]=[C:22]([O:27][CH3:28])[CH:23]=4)[CH:18]=3)[CH2:11][CH2:10]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>CO>[ClH:1].[ClH:1].[N:3]1([CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][C@@H:16]([C:29]3([OH:35])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)[C:17]3[CH:26]=[CH:25][C:24]4[C:19](=[CH:20][CH:21]=[C:22]([O:27][CH3:28])[CH:23]=4)[CH:18]=3)[CH2:13][CH2:14]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 68852257HCID 68852257, compound

Product 1

HCID 68852181HCID 68852181, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Racemic 1-[2-(1,4′-bipiperidin-1′-yl)-1-(6-methoxy-2-naphthyl)ethyl]cyclohexanol (see Example 346) was dissolved in methanol at a concentration of approximately 50 mg/mL. The resulting solution was injected onto the Supercritical Fluid Chromatography instrument. The baseline resolved enantiomers, using the conditions described below, were collected. The enantiomeric purity of each enantiomer was determined under the same Supercritical Fluid Chromatography conditions using a Chiralcel OJ-H 5u, 250 mm×4.6 mm ID column at 2.0 mL/min flow rate using Analytical Supercritical Fluid Chromatography (Berger Instruments, Inc. Newark, Del. USA).

Workup

  1. customwere collected

Sources & evidence

ORD record
ord-51c0e53f76e74152bf18cfdd4eb19a48
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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