HCID 68851895, compound → HCID 68855259, compound

HRID 902278Notes

Reaction equation

HRID 902278 reaction equation
[ClH:1].Cl.[O:3]([C:10]1[CH:11]=[C:12]([CH:16]([C:24]2([OH:30])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:17][N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:13]=[CH:14][CH:15]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[ClH:1].[ClH:1].[O:3]([C:10]1[CH:11]=[C:12]([C@H:16]([C:24]2([OH:30])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[CH2:17][N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[CH:13]=[CH:14][CH:15]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 68851895HCID 68851895, compound

Product 1

HCID 68855259HCID 68855259, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Racemic 1-[1-(3-phenoxyphenyl)-2-piperazin-1-ylethyl]cyclohexanol (see Example 311) was dissolved in methanol at a concentration of approximately 50 mg/mL. The resulting solution was injected onto the Preparative High Performance Liquid Chromatography instrument. The baseline resolved enantiomers, using the conditions described below, were collected. The enantiomeric purity of each enantiomer was determined under the same HPLC conditions using a Chiralcel OD-H 5 u, 250 mm×4.6 mm ID column at 1.0 mL/min flow rate using an HP 1100 HPLC (Agilent Technologies. Palo Alto, Calif., USA).

Workup

  1. customwere collected

Sources & evidence

ORD record
ord-a400b84018484bed94096cf4c3294662
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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