HCID 68852070, compound → HCID 68852667, compound

HRID 902280Notes

Reaction equation

HRID 902280 reaction equation
[ClH:1].Cl.CN[C@@H]1CCN(CC(C2CCCCC2O)C2C=CC3C(=CC=CC=3)C=2)C1.[OH:29][C:30]1([CH:36]([C:52]2[CH:61]=[CH:60][C:59]3[C:54](=[CH:55][CH:56]=[CH:57][CH:58]=3)[CH:53]=2)[C:37]([N:39]2[CH2:43][CH2:42][C@@H:41]([NH:44][C:45](=O)OC(C)(C)C)[CH2:40]2)=O)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>>[ClH:1].[ClH:1].[CH3:45][NH:44][C@@H:41]1[CH2:42][CH2:43][N:39]([CH2:37][CH:36]([C:30]2([OH:29])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]2)[C:52]2[CH:61]=[CH:60][C:59]3[C:54](=[CH:55][CH:56]=[CH:57][CH:58]=3)[CH:53]=2)[CH2:40]1

Participants

3

Reactant 2

HCID 68852070HCID 68852070, compoundHCID 86599049tert-butyl{(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate

Product 1

HCID 68852667HCID 68852667, compound

Procedure

In an analogous manner to Example 13, step 2, 1-[2-[(3R)-3-(methylamino)pyrrolidin-1-yl-1-(2-naphthyl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate. MS m/z 353; HRMS: calcd for C23H32N2O+H+, 353.25874; found (ESI, [M+H]+), 353.2583.

Sources & evidence

ORD record
ord-5cf5e809eb264fe690e311ca8b96aa79
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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