HCID 68851913, compound → HCID 68866142, compound

HRID 902284Notes

Reaction equation

HRID 902284 reaction equation
[ClH:1].Cl.[CH2:3](OC1C=CC(C2(O)CCCCC2CCN2CCN(C)CC2)=CC=1F)C1C=CC=CC=1.Cl.Cl.[CH2:36]([O:43][C:44]1[CH:49]=[CH:48][C:47]([CH:50]([C:58]2([OH:64])[CH2:63][CH2:62][CH2:61][CH2:60][CH2:59]2)[CH2:51][N:52]2[CH2:57][CH2:56][NH:55][CH2:54][CH2:53]2)=[CH:46][C:45]=1[F:65])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[ClH:1].[ClH:1].[CH2:36]([O:43][C:44]1[CH:49]=[CH:48][C:47]([CH:50]([C:58]2([OH:64])[CH2:59][CH2:60][CH2:61][CH2:62][CH2:63]2)[CH2:51][N:52]2[CH2:57][CH2:56][N:55]([CH3:3])[CH2:54][CH2:53]2)=[CH:46][C:45]=1[F:65])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Participants

3

Reactant 2

HCID 68851913HCID 68851913, compoundHCID 86599055HCID 86599055, compound

Product 1

HCID 68866142HCID 68866142, compound

Procedure

In an analogous manner to Example 24, 1-[1-[4-(benzyloxy)-3-fluorophenyl]-2-(4-methylpiperazin-1-yl)ethylcyclohexanol dihydrochloride was prepared from 1-{1-[4-(benzyloxy)-3-fluorophenyl]-2-piperazin-1-ylethyl}cyclohexanol dihydrochloride (See Example 413). MS (ES) m/z 427.1; HRMS: calcd for C26H35FN2O2+H+, 427.27553; found (ESI, [M+H]+), 427.2756.

Sources & evidence

ORD record
ord-0f8aed9fe4ff48fcade8ec7c351de6c2
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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