HCID 68853754, compound → HCID 11476950, compound

HRID 902286Notes

Reaction equation

Cl.Cl.[CH2:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([C:28]2([OH:34])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:18][N:19]2[CH2:24][CH2:23][CH:22]([N:25]([CH3:27])[CH3:26])[CH2:21][CH2:20]2)=[CH:13][C:12]=1[Cl:35])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl.Cl.NC1CCN(CC(C2(O)CCCCC2)C2C=CC(OCC3C=CC=CC=3)=C(Cl)C=2)CC1>>[CH2:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([C:28]2([OH:34])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:18][N:19]2[CH2:20][CH2:21][CH:22]([N:25]([CH3:27])[CH3:26])[CH2:23][CH2:24]2)=[CH:13][C:12]=1[Cl:35])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 68853754HCID 68853754, compound

HCID 68854020HCID 68854020, compound

Product 1

HCID 11476950HCID 11476950, compound

Procedure

In an analogous manner to Example 36 1-{1-[4-(benzyloxy)-3-chlorophenyl]-2-[4-(dimethylamino)piperidin-1-yl]ethyl}cyclohexanol dihydrochloride was prepared from {2-(4-aminopiperidin-1-yl)-1-[4-(benzyloxy)-3-chlorophenyl]ethyl}cyclohexanol dihydrochloride (See Example 428). MS (ESI) m/z 471; HRMS: calcd for C28H39ClN2O2+H+, 471.27728; found (ESI, [M+H]+), 471.2786.

Sources & evidence

ORD record: ord-70c5331fd3414613b7e3ef2c694703a1
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365076B2

Reaction notes

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