Sodium Azide → HCID 86609101, compound

Participants

Reaction Steps

A solution of [(2R)-8-(2-chlorophenyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.24 g, 0.56 mmol) and sodium azide (0.15 g, 2.24 mmol) in anhydrous dimethyl sulfoxide (10 mL) was heated to 70° C. under nitrogen for 15 hours. The cooled reaction mixture was then diluted with diethyl ether (50 mL), washed with water (5×25 mL) and saturated brine (25 mL), dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford 0.14 g (82%) of {[(2R)-8-(2-chlorophenyl)-3,4-dihydro-2H-chromen-2-yl]methyl}azide as a colorless oil that was used without further purification.

Provenance & Evidence