HCID 86609134, compound → HCID 86609133, compound

Participants

Reaction Steps

To a solution of (2R)-2-(6-chloro-2′-methyl-3-(prop-1-enyl)biphenyl-2-yloxy)but-3-enyl 4-methylbenzenesulfonate (1.4 g, 2.9 mmol) in 1,2-dichloroethane (30 mL) was added benzylidene-bis(tricyclohexylphosphine)dichlororuthenium (0.57 g, 0.69 mmol) and the resulting mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure. Purification by ISCO using a solvent gradient of 0 to 20% ethyl acetate in hexanes provided 0.8 g (63%) of ((2R)-7-chloro-8-o-tolyl-2H-chromen-2-yl)methyl 4-methylbenzenesulfonate as a thick dark oil.

Provenance & Evidence