HCID 86609138, compound → HCID 86609137, compound

Participants

Reaction Steps

To a solution of (2R)-2-(2′,6-dichloro-3-(prop-1-enyl)biphenyl-2-yloxy)but-3-enyl 4-methylbenzenesulfonate (3.0 g, 5.96 mmol) in 1,2-dichloroethane (60 mL) was added benzylidene-bis(tricyclohexylphosphine)dichlororuthenium (1.5 g, 1.82 mmol) and the resulting mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure. Purification by ISCO using a solvent gradient of 0 to 20% ethyl acetate in hexanes provided 2.15 g (78%) of ((2R)-7-chloro-8-(2-chlorophenyl)-2H-chromen-2-yl)methyl 4-methylbenzenesulfonate as an off-white solid. MS (ESI) m/z 460.9 ([M+H]+); m/z 477.9 ([M+NH4]+).

Provenance & Evidence