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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 902362Generated: October 26, 2026

1-Bromo-2-chlorobenzene → 2'-Chloro-2-fluoro-6-methoxybiphenyl

https://huagongshe.com/reaction/902362

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-chlorobenzeneHCID 12754—
Reactant(2-Fluoro-6-methoxyphenyl)boronic acidHCID 3294524—
SolventWater 1,2-dimethoxyethaneHCID 18180031—
Product2'-Chloro-2-fluoro-6-methoxybiphenylHCID 68961415122.2%

Reaction Steps

Treatment of 2-bromochlorobenzene (9 mL, 77.6 mmol) with 2-fluoro-6-methoxybenzene boronic acid (10.0 g, 58.8 mmol) in DME-water (5:1, 250 mL) according to the procedure described for Example 69, Step 1 provided 17.0 g of 2′-chloro-2-fluoro-6-methoxybiphenyl as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07365095B2
Source datasetuspto-grants-2008_04
ORD IDord-764ca2ed0d954074b221b7f34c87de3f
Source noteuspto-grants-2008_04