HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → (2R)-2-(azidomethyl)-8-(2-chlorophenyl)-7-fluorochroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | ((2R)-8-(2-chlorophenyl)-7-fluorochroman-2-yl)methyl 4-methylbenzenesulfonate | HCID 86609143 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (2R)-2-(azidomethyl)-8-(2-chlorophenyl)-7-fluorochroman | HCID 86609144 | 67% |
Reaction Steps
Treatment of ((2R)-8-(2-chlorophenyl)-7-fluorochroman-2-yl)methyl 4-methylbenzenesulfonate (0.7 g, 1.56 mmol) with sodium azide (0.61 g, 9.40 mmol) in DMSO (20 mL) according to the procedure described for Example 69, Step 9 provided 0.33 g (67%) of (2R)-2-(azidomethyl)-8-(2-chlorophenyl)-7-fluorochroman as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365095B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-9ff49f62874d4c1ea3c57239158f78dd |
| Source note | uspto-grants-2008_04 |