HCID 86609146, compound → HCID 86609145, compound

Participants

Reaction Steps

Treatment of (2R)-2-(4′-chloro-6-fluoro-2′-methyl-3-(prop-1-enyl)biphenyl-2-yloxy)but-3-enyl 4-methylbenzenesulfonate (1.35 g, 2.69 mmol) with benzylidene-bis(tricyclohexylphosphine)dichlororuthenium (0.70 g, 0.85 mmol) in methylene chloride (30 mL) according to the procedure described for Example 69, Step 7 provided 0.5 g (41%) of ((2R)-8-(4-chloro-2-methylphenyl)-7-fluoro-2H-chromen-2-yl)methyl 4-methylbenzenesulfonate as a brown oil.

Provenance & Evidence